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Men and women with type 1 long QT syndrome (LQT1) exhibit time-dependent differences in the risk for cardiac events. We hypothesized that sex-specific risk for LQT1 is related to the location and function of the disease-causing mutation in the KCNQ1 gene. The risk for life-threatening cardiac events (comprising aborted cardiac arrest [ACA] or sudden cardiac death [SCD]) from birth through age...
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