Search results for: Antonello Pietrangelo

Items from 1 to 20 out of 80 results

article

Labile plasma iron and echocardiographic parameters are associated with cardiac events in β‐thalassemic patients

Francesca Ferrara, Francesca Coppi, Roberta Riva, Paolo Ventura, more

European Journal of Clinical Investigation > 53 > 5 > n/a - n/a

Background and Aim Notwithstanding the improvement in therapies, patients affected by thalassemia major (TM) and intermedia (TI) are still at high risk of cardiac complications. This study aimed at evaluating the incidence and predictive factors for developing cardiac events in adult β‐TM and TI patients. Population and Methods Data on diagnosis and clinical history were collected retrospectively;...

article

Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients

Sebastiano Cicco, Marco D′Abbondanza, Marco Proietti, Vincenzo Zaccone, more

European Journal of Clinical Investigation > 53 > 4 > n/a - n/a

Background Hypertension management in older patients represents a challenge, particularly when hospitalized. Objective The objective of this study is to investigate the determinants and related outcomes of antihypertensive drug prescription in a cohort of older hospitalized patients. Methods A total of 5671 patients from REPOSI (a prospective multicentre observational register of older Italian...

article

Hyperferritinemia and diagnosis of type 1 Gaucher disease

Giacomo Marchi, Fabio Nascimbeni, Irene Motta, Fabiana Busti, more

American Journal of Hematology > 95 > 5 > 570 - 576

article

Impact of natural neuromedin‐B receptor variants on iron metabolism

Raffaela Rametta, Paola Dongiovanni, Guido A. Baselli, Serena Pelusi, more

American Journal of Hematology > 95 > 2 > 167 - 177

Iron overload heritability remains partly unexplained. By performing whole exome sequencing in three patients with a clinical phenotype of hemochromatosis not accounted by known genetic risk factors, we identified in all patients rare variants predicted to alter activity of Neuromedin‐B receptor (NMBR). Coding NMBR mutations were enriched in 129 patients with hereditary hemochromatosis or iron overload...

article

Evaluating the association of serum ferritin and hepatic iron with disease severity in non‐alcoholic fatty liver disease

Elena Buzzetti, Salvatore Petta, Roberta Manuguerra, Tu Vinh Luong, more

Liver International > 39 > 7 > 1325 - 1334

Background & Aims Hyperferritinemia, with or without increased hepatic iron, represents a common finding in non‐alcoholic fatty liver disease (NAFLD). However, it is unclear whether it reflects hepatic inflammation or true iron‐overload and, in case the latter is confirmed, whether this influences disease progression. We therefore explored the association between serum ferritin, degree and pattern...

article

Current challenges in the management of patients with sickle cell disease – A report of the Italian experience

Giovanna Russo, Lucia Franceschi, Raffaella Colombatti, Paolo Rigano, more

Orphanet Journal of Rare Diseases > 2019 > 14 > 1 > 1-9

Sickle cell disease (SCD) is an inherited red blood cell disorder caused by a structural abnormality of hemoglobin called sickle hemoglobin (HbS). Clinical manifestations of SCD are mainly characterized by chronic hemolysis and acute vaso-occlusive crisis, which are responsible for severe acute and chronic organ damage. SCD is widespread in sub-Saharan Africa, in the Middle East, Indian subcontinent,...

article

Safety and efficacy of sucrosomial iron in inflammatory bowel disease patients with iron deficiency anemia

Gianluca Abbati, Federica Incerti, Chiara Boarini, Francesca Pileri, more

Internal and Emergency Medicine > 2019 > 14 > 3 > 423-431

Iron deficiency anemia (IDA) is one of the most common complications of inflammatory bowel disease (IBD). We planned a prospective study to address tolerability and efficacy of sucrosomial iron, a new oral formulation of ferric pyrophosphate, in IBD patients. Thirty patients with a confirmed diagnosis of Crohn’s Disease (CD) or ulcerative colitis (UC) and mild IDA were enrolled. Patients with severe...

article

Clinical impact of application of risk assessment models (Padua Prediction Score and Improve Bleeding Score) on venous thromboembolism, major hemorrhage and health expenditure associated with pharmacologic VTE prophylaxis: a “real life” prospective and retrospective observational study on patients hospitalized in a Single Internal Medicine Unit (the STIME study)

Luca Depietri, Marco Marietta, Stefania Scarlini, Matteo Marcacci, more

Internal and Emergency Medicine > 2018 > 13 > 4 > 527-534

International guidelines recommend the use of pharmacological prophylaxis in hospitalized medical patients at high risk of venous thromboembolism (VTE). The same international guidelines suggest the employment of standardized risk assessment models (RAMs) when evaluating the administration of pharmacological prophylaxis in acutely ill medical patients. The Padua Prediction Score and the Improve Bleeding...

article

Human macrophage ferroportin biology and the basis for the ferroportin disease

Manuela Sabelli, Giuliana Montosi, Cinzia Garuti, Angela Caleffi, more

Hepatology > 65 > 5 > 1512 - 1525

Ferroportin (FPN1) is the sole iron exporter in mammals, but its cell‐specific function and regulation are still elusive. This study examined FPN1 expression in human macrophages, the cells that are primarily responsible on a daily basis for plasma iron turnover and are central in the pathogenesis of ferroportin disease (FD), the disease attributed to lack‐of‐function FPN1 mutations. We characterized...

article

Missed treatment in an Italian HBV infected patients cohort: HBV RER

Gianluca Cuomo, Vanni Borghi, Pietro Andreone, Marco Massari, more

Digestive and Liver Disease > 2016 > 48 > 11 > 1346-1350

Very little is known about the access to treatment for Chronic Hepatitis B in the real clinical practice and the characteristics of the patients who do not receive antiviral therapy.HBV-RER is an observational multicenter network that collected data of patients with HBV infection during a 3 years observational period (2009–2012).Among 2527 HBsAg positive patients, 1099 were never treated (NT); only...

article

Mechanisms of iron hepatotoxicity

Antonello Pietrangelo

Journal of Hepatology > 2016 > 65 > 1 > 226-227

article

An unfortunate case of post-ERCP complications

Massimo Fiorini, Antonello Pietrangelo, Alberto Vegetti

Internal and Emergency Medicine > 2017 > 12 > 2 > 263-265

article

Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis

Paolo Ventura, Giorgia Venturelli, Matteo Marcacci, Massimo Fiorini, more

Thrombosis Research > 2016 > 141 > Complete > 189-195

Portal vein thrombosis (PVT) is serious complication of liver cirrhosis (LC), especially in the presence of hepatocellular carcinoma (HCC). The liver plays a key role in homocysteine (Hcy) metabolism: mild hyperhomocysteinemia (HHcy) has been described in LC. HHcy is a risk factor for deep vein thrombosis. Methylen-tetrahydrofolate-reductase (MTHFR) C677T polymorphism is the commonest determinant...

article

Iron and the liver

Antonello Pietrangelo

Liver International > 36 > S1 > 116 - 123

Humans have evolved to retain iron in the body and are exposed to a high risk of iron overload and iron‐related toxicity. Excess iron in the blood, in the absence of increased erythropoietic needs, can saturate the buffering capacity of serum transferrin and result in non‐transferrin‐bound highly reactive forms of iron that can cause damage, as well as promote fibrogenesis and carcinogenesis in the...

article

Pathogens, Metabolic Adaptation, and Human Diseases—An Iron-Thrifty Genetic Model

Antonello Pietrangelo

Gastroenterology > 2015 > 149 > 4 > 834-838

article

Genetics, Genetic Testing, and Management of Hemochromatosis: 15 Years Since Hepcidin

Antonello Pietrangelo

Gastroenterology > 2015 > 149 > 5 > 1240-1251.e4

The discovery of hepcidin in 2000 and the subsequent unprecedented explosion of research and discoveries in the iron field have dramatically changed our understanding of human disorders of iron metabolism. Today, hereditary hemochromatosis, the paradigmatic iron-loading disorder, is recognized as an endocrine disease due to the genetic loss of hepcidin, the iron hormone produced by the liver. This...

article

Reducing the risk of hospital admission: A call to action from the Italian Society of Internal Medicine

Rodolfo Sbrojavacca, Antonello Pietrangelo, Luigi Fenoglio, Francesco Violi, more

European Journal of Internal Medicine > 2015 > 26 > 7 > 476-477

The belief that hospital stays may constitute per se a risk for patients is not widespread among patients and health care professionals. In the balance between advantages and disadvantages of admission, we rarely take into account the impact of the hospital stay itself on the well-being of the patient. In a society that is getting older the hospital may become a hostile environment for the complex...

chapter

Hepcidin and iron

Chiara Vecchi, Antonello Pietrangelo

Signaling Pathways in Liver Diseases > 400 - 410

This chapter focuses on the signaling pathways involved in the synthesis of hepcidin, the iron hormone, and discusses the pathophysiological consequences of genetic and nongenetic disruption of its regulation. Hepcidin acts as the principal physiological inhibitor of iron flux into the bloodstream by inhibiting its receptor, the iron exporter ferroportin. Hepcidin likely evolved to protect humans...

article

A pediatric case report of acute intermittent porphyria: Learning the lesson

Cristiano Rosafio, Patrizia Bergonzini, Stefano Marchini, Stefania Leoni, more

Digestive and Liver Disease > 2014 > 46 > Supplement 3 > e103

article

Impact of D181V and A69T on the function of ferroportin as an iron export pump and hepcidin receptor

Roman Praschberger, Melanie Schranz, William J.H. Griffiths, Nadja Baumgartner, more

BBA - Molecular Basis of Disease > 2014 > 1842 > 9 > 1406-1412

Mutations in the only known mammalian iron exporter ferroportin cause a rare iron overload disorder termed ferroportin disease. Two distinct clinical phenotypes are caused by different disease mechanisms: mutations in ferroportin either cause loss of iron export function or gain of function due to resistance to hepcidin, the peptide hormone that normally downregulates ferroportin. The aim of the present...

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INFONA - science communication portal

Search results for: Antonello Pietrangelo

Labile plasma iron and echocardiographic parameters are associated with cardiac events in β‐thalassemic patients

Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients

Hyperferritinemia and diagnosis of type 1 Gaucher disease

Impact of natural neuromedin‐B receptor variants on iron metabolism

Evaluating the association of serum ferritin and hepatic iron with disease severity in non‐alcoholic fatty liver disease

Current challenges in the management of patients with sickle cell disease – A report of the Italian experience

Safety and efficacy of sucrosomial iron in inflammatory bowel disease patients with iron deficiency anemia

Human macrophage ferroportin biology and the basis for the ferroportin disease

Missed treatment in an Italian HBV infected patients cohort: HBV RER

Mechanisms of iron hepatotoxicity

An unfortunate case of post-ERCP complications

Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis

Iron and the liver

Pathogens, Metabolic Adaptation, and Human Diseases—An Iron-Thrifty Genetic Model

Genetics, Genetic Testing, and Management of Hemochromatosis: 15 Years Since Hepcidin

Reducing the risk of hospital admission: A call to action from the Italian Society of Internal Medicine

Hepcidin and iron

A pediatric case report of acute intermittent porphyria: Learning the lesson

Impact of D181V and A69T on the function of ferroportin as an iron export pump and hepcidin receptor

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