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Here, we characterize the actions of MK-0767, a dual ligand of the nuclear receptors peroxisome proliferator-activated receptor (PPAR)α and PPARγ. In cell-based assays, MK-0767 produced potent activation of human PPARγ and PPARα with a γ:α potency ratio of ~2. The dual agonist induced high affinity interactions of PPARα and PPARγ with the transcriptional coactivator CBP in vitro. In ob/ob mice, MK-0767...
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