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An endogenous Na + , K + -ATPase inhibitor termed endobain E has been isolated from rat brain which shares several biological properties with ouabain. This cardiac glycoside possesses neurotoxic properties attributable to Na + , K + -ATPase inhibition, which leads to NMDA receptor activation, thus supporting the concept that Na + /K + gradient impairment...
We have shown that synaptosomal membrane Na + , K + -ATPase activity is stimulated or inhibited by norepinephrine according to the presence or absence of a brain soluble fraction. Gel filtration of such soluble fraction has allowed the separation of two fractions, peaks I and II, able to stimulate and inhibit Na + , K + -ATPase activity, respectively. Peak II behaves...
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