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Investigation on the absence of Δ6-desaturase activity in Nicotiana tabacum has led to the cloning of a new desaturase gene from this organism (NTDXDES) that exhibited unexpected biochemical activity. Cladistic analysis shows clustering of NTDXDES together with functional Δ6-acyl-desaturases of near Solanales plants, such as Borago and Echium. This group lies apart from that of previously characterised...
Recent studies have identified a new family of desaturase-like polypeptide sequences in many higher eukaryotes. Functional characterisation of one member of this family, from Schizosaccharomyces pombe, revealed the enzyme to be a sphingolipid desaturase. This S. pombe gene designated SDCB3b8.07c was identified as the dihydroceramide Δ 4 -desaturase, responsible for the synthesis of sphingosine...
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