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To determine the role of central serotonin 5-HT 3 receptors in respiratory motor control, respiratory motor bursts were recorded from hypoglossal (XII) nerve rootlets on isolated adult turtle brainstems during bath-application of 5-HT 3 receptor agonists and antagonists. mCPBG and PBG (5-HT 3 receptor agonists) acutely increased XII burst frequency and regularity, and decreased...
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