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Glucose-dependent insulinotropic polypeptide (GIP) is an important gastrointestinal hormone, which regulates insulin release and glucose homeostasis, but is rapidly inactivated by enzymatic N-terminal truncation. Here we report the enzyme resistance and biological activity of several Glu 3 -substituted analogues of GIP namely; (Ala 3 )GIP, (Lys 3 )GIP, (Phe 3 )GIP,...
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