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Sulfur mustard (SM)-induced lung injury has been associated with protease activation, oxidative injury and inflammatory response culminating in tissue necrosis. The protease inhibitors aprotinin and ilomastat and the antioxidant trolox were evaluated for efficacy in ameliorating SM-induced lung injury. Anesthetized spontaneously breathing rats (N=6–8/group) were intratracheally intubated and exposed...
microRNAs (miRNAs) are a large family of small regulatory RNA molecules found in all multicellular organisms. Since their discovery in 2001, there has been impressive progress in miRNA research, and a great deal is now known about the biosynthesis of miRNAs and their regulatory role in translation. It is becoming increasingly clear that miRNAs have fundamental roles to play in cellular responses to...
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