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Key points
According to the metabolon hypothesis, direct association of cytosolic carbonic anhydrases (CAs) with the electrogenic Na/HCO3 cotransporter NBCe1‐A speeds transport by regenerating/consuming . The present work addresses published discrepancies as to whether cytosolic CAs stimulate NBCe1‐A, heterologously expressed in Xenopus oocytes.
We confirm the essential elements of the...
• Cystic fibrosis (CF) is a common genetic disease caused by loss‐of‐function mutations in the cystic fibrosis transmembrane conductance regulator gene, which encodes a channel protein, selective for anions.
• In the lungs, the site of the most severe symptoms, CF causes abnormal electrolyte transport in epithelial cells which line the airways.
• Airway epithelial ion transport can be assessed by...
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