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QSAR model development of 37 phenyl benzoxazole was carried out to predict the fold selectivity for estrogen receptor. The ratio of IC50 for estrogen receptor-α and estrogen receptor-β (fold selectivity) was taken as biological activity. Physicochemical parameters were calculated using Dragon software, version 1.11. Sequential multiple linear regression analysis was carried out to derive QSAR models,...
The incidence of breast cancer is rising throughout the world. Breast cancer is slowly becoming more prevalent in countries which previously had low rates of cancer as well as becoming a leading cause of cancer death in some countries. Fortunately, a large number of these tumors are estrogen receptor (ER) positive and respond to anti-hormonal adjuvant therapy which until recently has been 5 years...
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