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The frequency and mechanism of p16 INK4A and p14 ARF gene alterations were studied in cell samples from 30 patients with Philadelphia (Ph) chromosome-positive chronic myeloid leukaemia (CML), both at diagnosis and at the onset of the accelerated phase (AP) of the disease. No alterations in the p16 INK4A or p14 ARF genes were found in any of the chronic phase (CP) samples...
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