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Introduction The kinesin family number 3A (KIF3A) gene on the human chromosomal 5q31–33 region, which is known as a susceptibility locus for immune diseases including asthma, plays a crucial role in generation of cilia. Results A treatment with aspirin in the human bronchial epithelial cells increased the mRNA expression level of KIF3A compared to that of the untreated control (P ≤ 0.01), and nasal...
Asthma is a chronic inflammatory disorder of the airways, and a number of genetic loci are associated with the disease. Candidate gene association studies have been regarded as effective tools to study complex traits. Knowledge of the sequence variation and structure of the candidate genes is required for association studies. Thus, we investigated the genetic variants of 32 asthma candidate genes...
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