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Rationale Alcohol dependence is the third leading cause of preventable death in the USA. While single-agent pharmacotherapies have variable efficacy, medication combinations may produce additive effects by modulating multiple neural pathways. Objectives Here, we examined in animal models of ethanol consumption and relapse the combined effects of ondansetron (a serotonin-3 antagonist) and topiramate...
Rationale Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. Objectives We undertook this preclinical study in order to establish topiramate’s efficacy in a rodent model and to determine whether topiramate’s efficacy may vary with level of drinking and/or genetic background. Methods The effects...
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