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Τhe expression of the critical initiator cytokine TNF-α was strongly upregulated in vivo in acute necrotic pancreatitis (AP) in rodents and in vitro in TNF-α activated acinar AR42J cells. Upregulation of tnf-α, inos,icam-1 and il-6 occurred both in TNF-α receptor 1 and 2 knock-out mice, but not in TNF-α knock-out mice, in cerulein-induced acute pancreatitis. Chromatin immunoprecipitation analysis...
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