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[18F]FDG has been the most widely used as the PET tracer for detecting brain and systemic tumors, however, [18F]FDG uptake in adjacent normal brain tissue is so strong that [18F]FDG-PET imaging could not give an effect for brain functional imaging. In order to develop new PET radiopharmaceuticals to complement [18F]FDG, a simple method for automatic synthesis of ethyl [18F]fluoroacetate which can...
A simple, rapid and fully automated preparation of [18F]1-amino-3-fluorocyclobutane-l-carboxylic acid ([18F] FACBC) has been developed on a commercial [18F]FDG synthesizer, the TRACERlab MXFDG. The reaction conditions, including reaction temperature, reaction time and precursor amount, were investigated in the F-18 labeling reaction. The hydrolysis reaction of the intermediate and purification process...
A simple and fast method for preparation of ethyl [18F]fluoroacetate which can be operated by remote control has been established, using distillation for purification. By this development, it has become possible to obtain ethyl [18F]fluoroacetate in a short synthesis time of 29 min and with a reproducible radiochemical yield of 28.6 plusmn 3.6 %, (decay corrected). The radiochemical purity of ethyl...
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