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We hypothesised that the polymorphisms of the genes encoding for β1- and the β2-adrenoceptors may have a role in the pathogenesis of heart failure (HF). We therefore compared the polymorphisms of the β1-adrenoceptor gene (Arg389Gly), the β2-adrenoceptor gene (Arg16Gly, Gln27Glu) and their combinations in patients with HF and normal subjects living in the same area.A total of 256 cases with HF (left...
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