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A variety of hereditary spinocerebellar ataxia (SCA) develops a broad spectrum of both ataxia and non-ataxia symptoms. Cognitive and affective changes are one such non-ataxia symptoms, but have been described only in hereditary SCAs with exonic CAG gene expansion.We newly found intronic hexanucleotide GGCCTG gene expansion in NOP56 gene as the causative mutation (=SCA36) in nine unrelated Japanese...
There are a number of clinical scores to measure cognitive impairment and behavioral and psychological symptoms of dementia (BPSD) for dementia patients.Previous BPSD scores are well established, but they usually take long time. Furthermore they were made almost 20 years ago, and therefore may not even fit a current BPSD because affective expressions may change depending on modern society change.To...
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