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Imidazo[1,2-a]pyrimidines and imidazo[1,2-b][1,2,4]triazines are ligands for the benzodiazepine binding site of GABA A receptors that are functionally selective for the α2/α3 subtypes over the α1 subtype. SAR studies to optimise this functional selectivity, pharmacokinetic and behavioural data are described.
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