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. Objective and Design: To examine whether inhibitors of the MAPK pathways will influence the response of bovine chondrocytes cultured in agarose constructs to IL-1β and dynamic compression. Methods: Dose-response studies were conducted under IL-1β conditions with either SB203580, SP600125, PDTC or curcumin. In separate experiments, constructs were treated with IL-1β and an appropriate concentration...
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