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Background
Children at high risk for prolonged mechanical ventilation (PMV) after liver transplantation (LT) need to be identified early to optimize pulmonary support, allocate resources, and improve surgical outcomes. We aimed to develop and validate a metric that can estimate risk for Prolonged Ventilation After LT (PROVE‐ALT).
Methods
We identified preoperative risk factors for PMV by univariable...
Oligodendrocytes produce lipid‐rich myelin sheaths that provide metabolic support to the underlying axon and facilitate saltatory conduction. Oligodendrocyte mitochondria supply the bulk of energy and carbon‐chain backbones required for lipid synthesis. The sparsity of mitochondria in the myelin sheath suggests that tight regulation of mitochondrial trafficking is crucial for their efficient distribution...
Cover Illustration: Confocal image of a mature oligodendrocyte in vitro following the addition of netrin‐1, immuno‐labelled for the mitochondrial docking protein syntaphilin (red), the outer mitochondrial membrane protein TOM20 (green), myelin basic protein (white), and Hoechst dye (blue). Syntaphilin is associated with mitochondria in mature oligodendrocytes and recruited to cell processes by netrin‐1...