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The receptor systems for the hemopoietic cytokines GM-CSF, IL-3, and IL-5 consist of ligand-specific α receptor subunits that play an essential role in the activation of the shared βc subunit, the major signaling entity. Here, we report the structure of the complete βc extracellular domain. It has a structure unlike any class I cytokine receptor described thus far, forming a stable interlocking dimer...
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