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Slow conduction through the Purkinje-ventricular junction (PVJ) is thought to result in conduction block and ultimately re-entry under certain pathological conditions. The relationships between tissue structure, conduction velocity and the safety of conduction at such junctions however, are unknown. We developed an electrophysiologically detailed 3D model of the PVJ and varied the Purkinje fibre thickness...
Purkinje fiber (PF) cells exhibit action potential (AP) morphology and duration markedly different to those of ventricle myocytes. In order to study heterogeneity at the Purkinje-ventricular junction (PVJ), we construct a new AP model for the canine PF cell based on detailed experimental data of ion channel characteristics obtained by voltage clamp techniques. Single-cell PF model is incorporated...
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