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Implantable biomedical devices generally comprise MEMS-type sensors used to acquire physiological signals, as well as CMOS electronics to perform powering, signal conditioning and data transmission. Among their requirements, reliability over an extended period of time ought to be spotlighted. Thus, modeling and realistic fault injection is essential to improve their long-term results. This work targets...
The ischemic cardiopathy is the main cause of death in developed countries. New improved drugs and therapies have appeared last years. However, the interventionist strategy and the most powerful drugs may have complications, and hence, it is very important to know the risk of death associated with patients during their stay in the hospital, or in the next six months. Thus, it is possible to tune the...
Lidocaine is a drug that blocks the sodium channel in a pH, frequency and concentration dependent manner. In this work, we have used a mathematical model of lidocaine developed by our group and incorporated it into the Luo Rudy model of ventricular action potential. We have studied the action of lidocaine on the sodium current (INa), maximum upstroke velocity (dV/dt) and conduction velocity (CV) in...
Lidocaine is a class I antiarrhytmic drug that blocks the sodium channels. This drug is a tertiary amine and exists as an uncharged free amine and cationic protonated form at physiologic pH. Experimental data have shown that the rate of development and recovery of block is slowed at low pH. In this work, a mathematical model of lidocaine effects has been developed. This model has been incorporated...
Lidocaine is used as an antiarrhythmic drug, its effectiveness is based on its ability to induce use- dependent block of cardiac sodium channels. This drug has an effect on conduction velocity (CV) and effective refractory period (ERP). Changes in CV and ERP could have an important role in the induction or suppression of reentrant circuits. We have studied the effect of lidocaine on CV, ERP and the...
Excellence in care optimisation in modern cardiology is a twofold issue that involves both the collaboration of numerous communities that benefit from collaborative work spaces as well as life-long education of professionals. Progressive specialisation of medical professionals is one of the factors that most account for this lack of dissemination giving way to the creation of clustered and specialised...
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