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Introduction
Nonacog beta pegol (N9‐GP) is a glycoPEGylated recombinant factor IX (FIX) with an extended half‐life developed for routine prophylaxis and the prevention and treatment of bleeding episodes in patients with haemophilia B.
Aim
The aim of this study was to evaluate the pharmacokinetics (PK) of N9‐GP.
Methods
Data from 41 previously treated haemophilia B patients, enrolled globally...
Background
Continuous infusion (CI) of recombinant FVIII (rFVIII) concentrates has been reported as an effective and safe method to achieve haemostasis during major surgeries or severe bleeding events. For more effective and safer CI, better understanding of in vivo recovery (IVR) and clearance (CL) issues is imperative.
Objective
We investigated the following factors affecting IVR and CL using...
IntroductionDosage adjustment is very important to perform continuous infusion (CI) of recombinant factor IX (rFIX) concentrates more effectively and economically, and clearance (CL) is strongly related to the infusion rate. However, previous reports have shown that the CL of rFIX concentrates varies widely (4.2–11.4 mL kg−1 h−1).
AimThe goal of this study was to gain a better understanding of the...
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