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Current biomarkers for myocardial infarction (MI) diagnosis are typically late markers released upon cell death, incapable of distinguishing between ischemic and reperfusion injury and can be symptoms of other pathologies. Circulating microRNAs (miRNAs) have recently been proposed as alternative biomarkers for MI diagnosis; however, detecting the changes in the human cardiac miRNA profile during MI...
Myocardial Infarction Diagnosis
To address the limitations of current myocardial infarction (MI) detection technology, in article 2201330, Pinar Zorlutuna and co‐workers develop the human heart anoxia and reperfusion tissue (HEART) model combined with a near real‐time microRNAs (miRNAs) concentration sensor for analysis of miRNAs under MI conditions. This model provides a modular, physiologically...
Aims
CONCERT‐HF is an NHLBI‐sponsored, double‐blind, placebo‐controlled, Phase II trial designed to determine whether treatment with autologous bone marrow‐derived mesenchymal stromal cells (MSCs) and c‐kit positive cardiac cells (CPCs), given alone or in combination, is feasible, safe, and beneficial in patients with heart failure (HF) caused by ischaemic cardiomyopathy.
Methods and results
Patients...