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The Multiple Sclerosis (MS) diagnosis is based on dissemination of focal lesions in time and space. The free light chains (FLCs) determination might be a sensitive alternative to oligoclonal bands assay. The study aim was to redefine sensitivity, specificity of the kFLC Index cut-off. We analyzed serum and cerebrospinal fluid of 176 patients, with different neurological disorders. We obtained a cut...
•Nephelometric approach for the analysis of kappa Free Light Chains•The use of kFLC Index as an aid in the diagnosis of Multiple Sclerosis•kFLC Index specificity and sensitivity to diagnose Multiple Sclerosis is better than other analytical methods used.
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