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In this study 117 panic disorder patients were divided into a respiratory subtype group and a non-respiratory subtype group. The respiratory subtype patients were observed to be more sensitive to the 35% CO 2 inhalation challenge test and the hyperventilation test than the non-respiratory subtype patients.
We examined whether responses to the carbon dioxide (CO 2 ) challenge test were correlated with clinical response. Thirty-four panic disorder patients participated in a CO 2 test after 1 h, 2 weeks and 6 weeks of treatment with clonazepam (2 mg/day) or placebo. The clonazepam group had significantly fewer panic attacks in response to the CO 2 test and the test may predict clinical...
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