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A marked and significant reduction of protease nexin-1 (PN-1) and PN-2/amyloid β protein precursor (AβPP) was observed in selected regions of Alzheimer's disease (AD) brains as compared to those of aged-matched controls. Correlative analysis indicated a relationship between PN-1 reduction and the severity of pathologic alterations. A statistically significant inverse correlation was noted between...
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