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ObjectiveTo investigate the role of hippocampal plasticity in the antidepressant effect of electroconvulsive therapy (ECT).
MethodWe used magnetic resonance (MR) imaging including diffusion tensor imaging (DTI) and proton MR spectroscopy (1H‐MRS) to investigate hippocampal volume, diffusivity, and metabolite changes in 19 patients receiving ECT for severe depression. Other regions of interest included...
Global brain ischemia provoked by transient occlusion of the carotid arteries (2VO) in gerbils results in a severe loss of neurons in the hippocampal CA1 region. We measured the concentration of the neuron specific N-acetyl-aspartate, [NAA], in the gerbil dorsal hippocampus by proton MR spectroscopy ( 1 H-MRS) in situ, and HPLC, 4 days after global ischemia. The [NAA] was correlated with graded...
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