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Key points
During compensated hypertrophy in vivo fractional shortening (FS) remains constant until heart failure (HF) develops, when FS decreases from 70% to 39%.
Compensated hypertrophy is accompanied by an increase in INa,late and a decrease in Na+,K+‐ATPase current. These changes persist as HF develops.
SR Ca2+ content increases during compensated hypertrophy then decreases in HF. In healthy...
In atrial myocytes, the sarcoplasmic reticulum (SR) has an essential role in regulating the force of contraction as a consequence of its involvement in excitation–contraction coupling (ECC). Nicotinic acid adenine dinucleotide phosphate (NAADP) is a Ca 2+ mobilizing messenger that acts to release Ca 2+ from an acidic store in mammalian cells. The photorelease of NAADP in atrial myocytes...
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