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Objectives
The primary objective of this study was to compare the therapeutic predictive value of area under the curve (AUC24) versus maximum concentration (Cmax) in cystic fibrosis (CF) patients receiving intravenous (IV) tobramycin for a Pseudomonas aeruginosa (PsA) acute pulmonary exacerbation (APE). Acute kidney injury (AKI) incidence and the relationship between time undetectable and efficacy...
Cystic fibrosis (CF) patients, with Pseudomonas aeruginosa infection, often require repeated aminoglycoside courses for the management of acute pulmonary exacerbations (APEs). Acute kidney injury (AKI) due to aminoglycosides has been reported; little data exist regarding long‐term nephrotoxicity with repeated exposure. The objective of this study was to describe the incidence of acute and chronic...
Study ObjectiveTo evaluate the pharmacokinetics and pharmacodynamics of ceftaroline in adults with cystic fibrosis (CF).
DesignOpen‐label, single‐center, prospective study.
SettingUniversity‐affiliated teaching institution.
PatientsEight patients with a diagnosis of CF and a history of methicillin‐resistant Staphylococcus aureus who were treated with ceftaroline between November 2013 and September...
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