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L’allopurinol est le traitement hypo-uricémiant (THU) le plus utilisé dans la prise en charge de la goutte. Bien qu’il existe depuis plus de 40 ans, son dosage optimal chez les patients goutteux souffrant d’insuffisance rénale chronique (IRC) reste controversé. La goutte étant fréquente chez les insuffisants rénaux, les cliniciens ont besoin de connaître les relations entre urate sérique (US) et fonction...
Allopurinol is the most commonly used urate lowering therapy in the management of gout. Despite the fact that it has been available for over 40 years there is ongoing debate about optimal allopurinol dosing in gout patients with chronic kidney disease. Given that gout is common in patients with renal impairment, clinicians need to be aware of the relationships between serum urate and kidney function...
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