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IL-4 is a type 2 cytokine that may mediate pleiotropic effects in the NSCLC microenvironment. Here, we investigated whether IL-4 regulates PGE 2 production in NSCLC cells. We found that IL-4 inhibited constitutive COX-2 expression and PGE 2 production in A427 and H2122 NSCLC cell lines, and also suppressed IL-1β-induced COX-2 expression in A549 and RH2 NSCLC cell lines. COX-2 mRNA...
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