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Puberty is a process that integrates multiple inputs ultimately resulting in an increase in gonadotrophin‐releasing hormone (GnRH) secretion. Although kisspeptin neurones play an integral role in GnRH secretion and puberty onset, other systems are also likely important. One potential component is nitric oxide (NO), a gaseous neurotransmitter synthesised by nitric oxide synthase (NOS). The present...
Puberty onset involves increased gonadotrophin‐release (GnRH) release as a result of decreased sensitivity to oestrogen (E2)‐negative feedback. Because GnRH neurones lack E2 receptor α, this pathway must contain interneurones. One likely candidate is KNDy neurones (kisspeptin, neurokinin B, dynorphin). The overarching hypothesis of the present study was that the prepubertal hiatus in luteinising hormone...
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