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Rotator cuff tears are among the most common shoulder injuries that require surgery. High failure rates of biological graft-based repairs underscore the need for functional alternatives. In this study, effects of nanofiber organization on adhesion of cuff fibroblasts (hRCF) and human mesenchymal stem cells (hMSC) are evaluated. It is hypothesized that fiber alignment will regulate cell morphology...
Rotator cuff tears are among the most common shoulder injuries that require surgery. High failure rates of biological graft-based repairs underscore the need for functional alternatives. Specifically, functional grafts must incorporate the gradient of mineralization from tendon to bone in order to be biomimetic. In this study, effects of varying concentrations of mineral content in aligned nanofiber...
Rotator cuff tears often occur at the tendon-bone insertion site, a fibrocartilaginous interface that is not regenerated during current repairs. Our aim is to regenerate the insertion site through use of extracellular matrix based scaffolds. In this study, we evaluated the response of mineralized and non-mineralized nanofiber scaffolds to cell culture environment without the influence of cell growth...
The regeneration of the tendon to bone insertion site affects how well the ACL heals. The addition of a calcium phosphate coating to a tendon graft can help to promote osteointegration and healing of the insertion. Patellar tendons were harvested from neonatal bovines and coated in semi-crystalline calcium phosphate. The tendons were subjected to two 5?? concentrated simulated body fluid solutions...
In this article, significant differences in cell growth and gene expression have been detected on PLGA and PCL scaffolds. Specifically, cell proliferation on the PCL based scaffolds has been found to be significantly greater than on the PLGA based scaffolds after four weeks in vitro. Results also suggest that differences in scaffold mechanical properties regulate the expression of key extracellular...
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