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Studies in both humans and animals demonstrate that d,l- and d-fenfluramine (d,l-FEN and d-FEN, respectively) can activate the hypothalamic-pituitary-adrenal axis following an acute dose. No data exist showing a prolonged effect of either drug, although two studies have hinted at increased adrenal activity. There are also considerable differences in the literature pertaining to the neurotoxic effects...
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