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This study focused on determining the concentration of zidovudine (AZT) and polystyrene sulfonate (PSS) in the plasma and vaginal tissue of the large white pig from an intravaginal bioadhesive polymeric device (IBPD). Biocompatible polymers were compressed with AZT and PSS into caplet‐shaped devices for insertion into the posterior fornix of the pig vagina. A total of 25 pigs were used in this study...
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