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Chromatographic separation of an extract of the stems of Sinomenium acutum resulted in the isolation of two new alkaloids, 2-O-demethyl-acutumine (4), and 6-O-methyl-laudanosoline-1-O-glucoside (5), together with three known alkaloids, sinomenine (1), sinomenine N-oxide (2), and magnoflorine (3). Sinomenine was found to show good inhibitory activity toward l-histidine decarboxylase from Lactobacillus...
The glycosidase-inhibiting pyrrolidine alkaloids (2R,3R,4R,5R)-2,5-dihydroxymethyl-3,4-dihydroxy-pyrrolidine (DMDP), 2,5-dideoxy-2,5-imino-dl-glycero-d-manno-heptitol (homoDMDP), homoDMDP-7-O-apioside and 1,4-dideoxy-1,4-imino-d-arabinitol have been identified in the leaves of bluebells (Hyacinthoides non-scripta). HomoDMDP and homoDMDP-7-O-apioside are new natural products. Glycosidase inhibition...
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