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Bevacizumab is the first vascular endothelial growth factor-targeted agent shown to increase survival in patients receiving first-and second-line intravenous 5-FU–based chemotherapy for the treatment of metastatic colorectal cancer. Bevacizumab is typically well tolerated and its major side effects include hypertension, proteinuria, bleeding, gastrointestinal perforation and arterial thrombotic events...
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