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Antibodies to CD40 have been demonstrated to promote B-cell growth and differentiationin vitro.In order to determine if CD40 stimulation could promote antigen-specific human immunoglobulin (Ig) productionin vivo,we examined the effects of anti-human CD40 MoAb in anin vivosystem where human peripheral blood lymphocytes (huPBL) were engrafted into mice with severe combined immune deficiency (SCID)....
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