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Pan-cancer analyses attempt to discover similar features among multiple cancers to identify fundamental patterns common to cancer development and progression. A pan-cancer analysis integrating both protein expression and transcriptomic data is important because it can identify genes that are linked to proteins potentially responsible for a patient's status. This study aims to identify differentially...
We developed a scalable distributed computing system using the Berkeley Open Interface for Network Computing (BOINC) to align next-generation sequencing (NGS) data quickly and accurately. NGS technology is emerging as a promising platform for gene expression analysis due to its high sensitivity compared to traditional genomic microarray technology. However, despite the benefits, NGS datasets can be...
Drug bioavailability is a major failing point of new pharmaceuticals i.e. drugs fail to reach their target or fail to stay there long enough for therapeutic effect. Compounding this issue, significant variability exists between patients and how they metabolize and distribute a drug. We present WebPK, a web-based tool for simulation of custom pharmacokinetic models. Model parameters can be entered...
January 2009, the forecasting ability of the Delft3D modeling suite was demonstrated in real time for an area in the Northern Gulf of Mexico. As part of the demonstration, a bathyme?trie survey was conducted, and several wave buoys of different types were deployed. Delft3D is a three-dimensional modeling suite that can also be run in depth-averaged mode to provide wave conditions, currents, changes...
This paper describes the conceptual model on corporate culture and knowledge management. Based on the 7-s model, this paper conceptualizes corporate culture, and conceives a model that describes the corporate cultural change process. A second model is offered for corporate cultural change in the context of knowledge management implementation where self-imposing mechanism plays a critical role. The...
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