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Methamphetamine (MA) is widely abused and implicated in residual cognitive deficits. In rats, increases in plasma corticosterone and egocentric learning deficits are observed after a 1‐day binge regimen of MA (10 mg/kg × 4 at 2‐h intervals). The purpose of this experiment was to determine if adrenal inactivation during and following MA exposure would attenuate the egocentric learning deficits in the...
In rats, neurotoxic doses of methamphetamine (MA) induce astrogliosis, long lasting monoamine reductions, reuptake transporter down-regulation, and learning impairments.We tested whether comparable effects occur in C57BL/6 mice.C57BL/6 mice were treated with 10mg/kgs.c.×4 MA on a single day and evaluated at various intervals thereafter.The neurotoxic dose regimen of MA caused the predicted acute hyperthermia...
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