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Background
Spinocerebellar ataxia type 12 (SCA12) is a neurodegenerative disease caused by expansion of a CAG repeat in the PPP2R2B gene.
Objective
In this study, we tested the hypothesis that the PPP2R2B antisense (PPP2R2B‐AS1) transcript containing a CUG repeat is expressed and contributes to SCA12 pathogenesis.
Methods
Expression of PPP2R2B‐AS1 transcript was detected in SCA12 human induced...