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Somatodendritic Kv4.2 channels mediate transient A-type potassium currents (I A ), and play critical roles in controlling neuronal excitability and modulating synaptic plasticity. Our studies have shown an NMDA receptor-dependent downregulation of Kv4.2 and I A . NMDA receptors are heteromeric complexes of NR1 combined with NR2A–NR2D, mainly NR2A and NR2B. Here, we investigate NR2B...
Nitric oxide (NO) has been shown to modulate autonomic function by acting both peripherally and centrally. A growing body of evidence indicates that the paraventricular nucleus of the hypothalamus (PVN), an important site for autonomic and endocrine homeostasis, constitutes an important locus mediating central NO actions. However, the cellular targets and mechanisms mediating NO actions within the...
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