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Hepatic oxidative stress is a key feature of metabolic forms of steatohepatitis, but the sources of pro-oxidants are unclear. The NADPH oxidase complex is critical for ROS generation in inflammatory cells; loss of any one component (e.g., gp91 phox ) renders NADPH oxidase inactive. We tested whether activated inflammatory cells contribute to oxidant stress in steatohepatitis.gp91 phox−/−...
While oxidative stress is a feature of non-alcoholic steatohepatitis, the causal link between oxidative stress and inflammatory recruitment has yet to be demonstrated. We analysed the role of NF-κB redox-sensitive signalling pathway of inflammatory recruitment in experimental steatohepatitis.Mice were fed the methionine and choline deficient (MCD) or the control diet, with or without curcumin, an...
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