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Cellular adhesion is regulated by the binding of 10 nm sized integrin to Arg‐Gly‐Asp (RGD) ligands present in extracellular matrix proteins. In this study, seed‐mediated growth of gold nanoparticles (AuNPs) on the surface of iron oxide (Fe3O4) nanotemplates is employed to tune the diameter and interdistance of RGD‐bearing AuNPs at the receptor‐level. The Fe3O4 nanotemplates decorated with RGD‐bearing...
Integrin Clustering
In article number 2200828, Young Keun Kim, Heemin Kang, and co‐workers report the dynamic tuning of receptor‐level ligand proximity. Closely spaced ligands coated onto subordinate nanostructures distributed on a nano‐template stimulate integrin binding and clustering. This activates the spreading, mechanotransduction, and differentiation of stem cells that occur in an active pro‐regenerative...
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