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As part of the Germ Cell Collaborative Study, we used the positive-selection Muta TM Mouse model to evaluate the effects of two direct alkylating agents, ethylnitrosourea (ENU) and methyl methanesulfonate (MMS), on male germ cells. The lacZ mutation frequency in seminiferous tubule cells and epididymis spermatozoa was measured 3, 14, 25 and 50 days after a single intraperitoneal (i.p...
We used the positive selection Muta ™ Mouse model to detect organ-specific activity of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) and β-propiolactone (BPL), two highly reactive alkylating agents known to induce genetic damage and tumors in rodent stomach when administered orally. Seven days alter a single oral administration of MNNG (100 mg/kg) or BPL (150 mg/kg), the mutation frequency in...
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