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A limited screen of several commercially-available and internally-produced lipases and esterases identified the lipase PS-800 as a suitable biocatalyst for the resolution of a racemic β-lactam benzyl ester to the (S)-acid. This β-lactam is a precursor to the elastase inhibitor L-694,458, an experimental drug targeted for the treatment of cystic fibrosis. Key to the development of a scalable process...
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