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SKP2 is the substrate recognition subunit of the ubiquitin ligase complex which targets p27 KIP1 for degradation. Induced at the G 1 /S transit of the cell cycle, SKP2 is frequently overexpressed in human cancers and contributes to malignancy. We previously identified SKP2 as a possible MYCN target gene and hence hypothesise that SKP2 is a potential therapeutic target in MYCN amplified...
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