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To observe the tissue-type plasminogen activator gene (t-PA) plasmid packaged with albumin nanoparticles crosslinked to albumin ultrasound microbubbles for targeting transfection to myocardium to prevent the graft thrombosis and vascular anastomotic restenosis after coronary bypass.A dog model of coronary bypass using the autoallergic saphenous vein as the graft was made. A highly expressive t-PA...
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